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Recent large cohort studies established that, within normal range, low serum PRL is associated with metabolic syndrome and obesity in children ( In concordance with epidemiologic studies, circulating levels of PRL are reduced in the ob/ob and db/db obese and diabetes mouse models, and in streptozocin-induced (STZ) T2DM rats

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Cocoa supplementation can also lower CD68 + neutrophils, MPO, TNF-, IL-1 and IL-17 and suppress STAT-3 activation in colitic tissues (204) ( Supplementary Table 1 )

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